Characteristic

Nonanxious Depression N = 1331

Anxious Depression N = 1299

p-value

Age, y, mean (SD)

Range

50.3 (17.5)

18 - 90

49.9 (17.5)

18 - 90

0.555

Gender, n (%)

Female Male

813 (61.1)

518 (38.9)

856 (65.9)

443 (34.1)

0.010

Race, n (%)

Caucasian Black/African American Hispanic Asian Native American Other

1033 (77.6)

129 (9.7)

144 (10.8)

14 (1.1)

1 (0.1)

10 (0.8)

940 (72.4)

143 (11.0)

190 (14.6)

15 (1.2)

1 (0.1)

10 (0.8)

0.050

Geography, n (%)

USA Europe Other

1265 (95.0)

5 (0.4)

61 (4.6)

1204 (92.7)

16 (1.2)

79 (6.1)

0.010

Prior Tx with antidepressant, n (%)

Any antidepressant

728 (54.7)

745 (57.4)

0.170

Duration of current MDD episode, mo, mean (SD)

18.9 (38.6)

17.3 (38.0)

0.441

Number of previous episodes of MDD, n, mean (SD)

5.1 (22.0)

5.5 (26.1)

0.628

CGI-S, mean (SD)

4.2 (0.7)

4.5 (0.7)

<0.0001

MADRS total score, mean (SD)

29.4 (4.6)

32.1 (4.9)

<0.0001

HAMD₁₇, mean (SD)

Total score Maier Retardation Sleep Bech Mood Anxiety/Somatization

17.6 (4.3)

9.5 (2.8)

6.8 (2.1)

3.3 (1.8)

10.1 (2.8)

7.7 (2.5)

4.7 (1.3)

23.6 (3.9)

11.7 (2.2)

7.8 (1.7)

3.8 (1.7)

12.5 (2.0)

9.0 (2.0)

8.3 (1.4)

<0.0001

<0.0001

<0.0001

<0.0001

<0.0001

<0.0001

<0.0001

HAMA total score, mean (SD)

12.7 (4.6)

18.3 (4.6)

<0.0001

BPI Average Pain, mean (SD)

3.4 (2.3)

4.5 (2.2)

<0.0001

BPI Interference Summary, mean (SD)

2.6 (2.5)

3.9 (2.8)

<0.0001

SDS total score, mean (SD)

17.8 (6.5)

20.0 (6.4)

<0.0001